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12/20/2023 0 Comments Lead poisoning antidoteThe study will be performed in the Pediatric Environmental Health Center of Children's Hospital Boston. The d-penicillamine product will be a newly developed, IND-approved liquid formulation. We propose to evaluate, in a Phase II/III randomized, placebo-controlled clinical trial, the effectiveness of d-penicillamine in 50 children aged 6 months to 16 years with blood lead levels 15-25 mcg/dl. Several studies have suggested that d-penicillamine is both safe and effective in the treatment of low-level lead poisoning. d-Penicillamine is a lead chelator that has been used off-label for almost 4 decades. For children with blood lead levels less than 45 mcg/dl treatment is fraught with difficulties including inconsistent recommendations by clinical experts, lack of proven benefit of chelation and the absence of a chelating agent approved for use in this range. Approved chelating agents for severe plumbism are CaNa2EDTA and succimer. 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